Medico-Legal Update

Hasyim As’ari Asnani ¹

Affiliations
1 Lecturer of Surabaya Health Ministry Polytechnic, ID

Abstract

Hypercholesterolemia contributes to the incidence of coronary heart disease which is the leading cause of death in the world¹. Diet modification and hypolipidemic drugs, including herba, one of which is Garcinia mangostana L. will effectively reduce total cholesterol³. A research a posttest control group design²⁰, type of research was a laboratory experimental research¹⁵. The population was male white mice aged 3 - 4 weeks weighing 100-200 grams¹². Hypercholesterolemia in male white rats was with MDLT induction (high - fat diet food)⁷. Data collection of total cholesterol levels measurement used enzymatic spectrophotometer method, data analysis used Variant Analysis statistical test (ANOVA) with significance level α < 0.05 15. The effect of Garcinia mangostana L. rind extract on total cholesterol reduction in white rats was grouped into a negative control group, positive control group and four dose treatment groups⁴. Identification of hypercholesterolaemia in white rats was examined for total cholesterol on day^8,16. The effect of Garcinia Mangostana L rind extract on reducing total cholesterol was examined on day^22,3,16. The results of the examination showed the administration of Garcinia mangostana L. rind extract in all dosage groups effectively reduced total cholesterol levels with a significance level of p < 0.05.

Keywords

Garcinia mangostana L, total cholesterol and hypercholesterolemia

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